Resetting protects efficiency of tubuloglomerular feedback
نویسندگان
چکیده
منابع مشابه
Connecting tubule glomerular feedback mediates acute tubuloglomerular feedback resetting.
Tubuloglomerular feedback (TGF) and connecting tubule glomerular feedback (CTGF) are mechanisms that control afferent arteriole (Af-Art) tone. TGF, initiated by increased NaCl at the macula densa, causes Af-Art constriction. Prolonged activation of TGF leads to an attenuation or "resetting" of its constrictor effect. The mechanisms of TGF resetting remain incompletely understood. CTGF is initia...
متن کاملResetting of exaggerated tubuloglomerular feedback activity in acutely volume-expanded young SHR.
One purpose of the present study was to evaluate the ability of 7-wk-old spontaneously hypertensive rats (SHR) to reset tubuloglomerular feedback (TGF) activity in response to acute volume expansion (VE). Second, we evaluated the contribution of ANG II, via its action on AT1 receptors, to TGF control of glomerular function during VE. TGF was assessed by micropuncture methods and proximal tubula...
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THE MACULA DENSA CELLS COMPRISE the sensing component of the tubuloglomerular feedback (TGF) mechanism and respond to changes in tubular fluid composition by transmitting signals to the afferent arterioles thus regulating the preglomerular vascular resistance and filtered load to the tubules (14, 15). This intriguing mechanism has remained under intensive investigation, and the accrued evidence...
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VARIATIONS OF NaCl concentration in the macula densa region of the tubule between 20 and 60 mM/l cause inverse changes in glomerular filtration rate (GFR) that, for the most part, are the result of a progressive increase in afferent arteriolar resistance and a subsequent fall in glomerular capillary pressure (5). The reductions in capillary pressure and GFR are rapidly inducible and rapidly rev...
متن کاملCalcium wave of tubuloglomerular feedback.
ATP release from macula densa (MD) cells into the interstitium of the juxtaglomerular (JG) apparatus (JGA) is an integral component of the tubuloglomerular feedback (TGF) mechanism that controls the glomerular filtration rate. Because the cells of the JGA express a number of calcium-coupled purinergic receptors, these studies tested the hypothesis that TGF activation triggers a calcium wave tha...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.06713.x